Safety of breast conservation therapy in BRCA1 and BRCA2 cancers
نویسندگان
چکیده
منابع مشابه
Re: Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.
BACKGROUND We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of...
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During the last two decays the tremendous success in molecular biology and genetics which has surprised the entire world. So that today the sequencing of whole genome has been possible for each human individual to estimate its being affected with cardiovascular and cancer diseases. However, these achievements have some important limitations and deep ethical issues which might be ignored. Geneti...
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Many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. Among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. Early detection of mutation carriers in these genes, in turn, can play an import...
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PURPOSE Germline mutations in the BRCA1 and BRCA2 genes confer increased susceptibility to ovarian cancer. There is evidence that tumors in carriers may exhibit a distinct distribution of pathological features, but previous studies on the pathology of such tumors have been small. Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian ca...
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E. Grzybowska, A. Jasinska, P. Kozlowski, H. Zientek, W. Krzyzosiak, B. Utracka-Hutka, J. Wloch and J. Rogozinska-Szczepka Department of Tumor Biology, Center of Oncology, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland Chemotherapy Clinic, Center of Oncology, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland Surgery Clinic, Center of Oncology, Maria Sklodowska-Curie Memoria...
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ژورنال
عنوان ژورنال: Breast Cancer Online
سال: 2004
ISSN: 1470-9031
DOI: 10.1017/s1470903104001981